Gastric Ulcer
The most common causes of peptic ulcers are infection with the bacterium Helicobacter pylori (H. pylori) and long-term use of aspirin and certain other painkillers, such as ibuprofen (Advil, Motrin, others) and naproxen sodium (Aleve, Anaprox, others). Stress and spicy foods do not cause peptic ulcers.Stomach and duodenal ulcers are usually due to one of two causes: the bacterium Helicobacter pylori or nonsteroidal anti — inflammatory drugs (NSAIDs) like aspirin, ibuprofen, and naproxen. An ulcer, regardless of the cause, can cause abdominal pain, bleeding, or even cause a hole (perforation).NSAIDs can cause damage to the gastroduodenal mucosa via several mechanisms, including the topical irritant effect of these drugs on the epithelium, impairment of the barrier properties of the mucosa, suppression of gastric prostaglandin synthesis, reduction of gastric mucosal blood flow and interference with the …